(3 customer reviews)

Inhibitory Neurotransmission Support

Prolent by Sanesco Health helps support inhibitory neurotransmission. This formula contains glycine, ingredients for serotonin synthesis, and ingredients to support GABA release and/or function.


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How it Works

Balance between inhibitory and excitatory neurotransmitters is vital to health and well-being. Inhibitory neurotransmitters such as serotonin, GABA and glycine control excitatory signals in the nervous system. That is why supporting inhibitory neurotransmitters often results in an overall calming and relaxing effect. Prolent by Sanesco Health includes ingredients that support the action of inhibitory neurotransmitters. 5-HTP and vitamin B6 support serotonin synthesis.

Theanine, as Suntheanine®, supports both the release of GABA and its function. The combination of these ingredients along with glycine allows Prolent to offer comprehensive support for inhibitory neurotransmission. This product may be used in Initial, Restoration and Maintenance phases along the path to patient wellness. It may be combined with LentraSomniTR, or Tranquilent for added inhibitory support.


GABA is important for:

  • Sleep
  • Calm and relaxation
  • Mood
  • Regulating excitability

Serotonin also plays important roles in:

  • Mental and emotional health
    (including mood and anxiousness)
  • Aggression
  • Learning
  • Stress response
  • Appetite and cravings
  • Pain perception
  • Libido
  • GI motility
  • Thermoregulation
  • Menstrual health
  • Sleep
  • Calm and relaxation

Muscle control and coordination Glycine is important in:

  • Pain perception
  • Detoxification
  • Connective tissue health
  • Sleep


  • L-theanine as Suntheanine® (standardized to >99%): Shown to promote relaxation by multiple mechanisms including antagonizing glutamate receptors, increasing the release of GABA, and decreasing norepinephrine levels in the brain.
  • 5-HTP:  A naturally occurring amino acid and metabolite of L– tryptophan. 5-HTP is the direct precursor in the biosynthesis of serotonin. Use of 5-HTP avoids the rate-limiting conversion of tryptophan to 5-HTP.
  • Glycine:  Functions as an inhibitory neurotransmitter, primarily in the brainstem and spinal cord.
  • Vitamin B6 (as pyridoxal-5’-phosphate):Active form of B6. Cofactor in conversion of 5-HTP to serotonin.
  • NeuroSupport Blend™(NSB):  Proprietary mixture composed of Bioperine® and plant-based enzymes clinically proven to maximize nutrient absorption.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60 Capsules

Prolent Formula – 295 mg  

  • Vitamin B6 (as pyridoxal-5-phosphate)
  • Glycine
  • L-theanine (as Suntheanine®)
  • 5-hydroxytryptophan (Griffonia simplicifolia) (seed)

NSB™ Proprietary Blend – 102.5 mg
BioPerine® (Black Pepper Extract) (standardized to 95% piperine)(Piper nigrum) (fruit)

  • Protease
  • Amylase
  • Lipase

NSB™ is a trademark of Sanesco International Inc.


BioPerine® is a registered trademark and a product of Sabinsa Corp.


Suntheanine® brand L-Theanine is a registered trademark of Taiyo International, Inc.Suntheanine® is Generally Recognized as Safe (GRAS) & is Non-GMO Project Verified. 

For more information regarding Sanesco and Targeted Nutritional Therapy TNT visit


Sanesco Health

Sanesco Health supplements and Targeted Nutritional Therapy (TNT), Communication System Management™ addresses the underlying causes of common health concerns with a proprietary system that analyzes neurotransmitter and hormone imbalances, provides personalized clinical data, and offers a targeted non-drug adjunct to existing treatment.
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3 reviews for Prolent

  1. Wesley

    Though I don’t typically believe in 5 star ratings, this product certainly deserves at least 4.5 stars! I have personally used Prolent for over 2 years and absolutely love it! Targeted Nutritional Therapy via NeuroLab testing has become a mainstay in establishing baseline neurotransmitter values while enabling our health coaches to implement neurotransmitter modulation protocols for all of our clients. I highly recommend taking your health and wellness to the next level by incorporating TNT into your program.

  2. Megan (verified owner)

    My husband has been taking Lentra, Adaptacin, Procite-D and Prolent for 9 months, following diagnosis by a naturopath that his feel-good transmitters were low. Within a couple weeks of being on all four supplements, I noticed he seemed happier, less irritated and/or anxious, and lighter hearted.

    In December 2021 he ran out of Procite-D and a supply chain issue meant waiting 6 weeks before receiving any. His cranky-pants returned and that’s when I realized the supplements *do* seem to help keep his feel-good levels higher than they would otherwise be on their own.

    I’m rating this 4 stars instead of 5 because the supplements are quite expensive, especially when taking four different types at once.

  3. Roman Spinale (verified owner)

    I have been taking this supplement for several years and do seem to notice a discernible change whenever I stop taking it. I take the Prolent in concert with the Procite D and Lentra, and believe this combination of supplements is highly effective for my mood support and neurotransmitter regulation.

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