Table of Contents
5-Hydroxytryptophan
5-Hydroxytryptophan (5-HTP) by Thorne, increases serotonin levels to promote restful sleep, manage stress, and decrease sugar cravings. It contains pyridoxal 5′-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin.
Ingredient Information
Key Ingredients
Ingredient Amounts
| Name | Amount |
|---|---|
| 5-Hydroxytryptophan | 100 mg |
| Vitamin B6 (Pyridoxal 5′-Phosphate) | 6.8 mg |
| Other Ingredients: Hypromellose Capsule, Leucine, Microcrystalline Cellulose, Silicon Dioxide |
How to Use
Take 1-2 capsules three times daily or as recommended by one of our health coach professionals.
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5-Hydroxytryptophan Details
The serotonin levels in the body are associated with the regulation of sleep, mood, and appetite. A balanced serotonin level has been shown to support restful sleep, good mood, and decreased sugar cravings. There are several ways to support a healthy serotonin level. L-tryptophan and 5-Hydroxytryptophan (5-HTP) are both precursors to serotonin.
However, supplementation with 5-HTP is preferable, because unlike L-tryptophan, 5-HTP cannot be shunted into other uses in the body, such as niacin or protein production. 5-HTP is well absorbed by the body and easily crosses the blood-brain barrier where it can increase the synthesis of serotonin in the central nervous system.
And 5-HTP can be taken with meals without reducing its effectiveness. 5-Hydroxytryptophan (5-HTP) is the intermediate metabolite the body produces when it initiates the process of converting the essential amino acid L-tryptophan to serotonin.
Therefore, supplementation with 5-HTP will bypass the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase – which is the rate-limiting step in the synthesis of serotonin – and is a conversion that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron.
5-HTP is well absorbed when taken orally, with about 70 percent going into the bloodstream. Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and its absorption is not affected by the presence of other amino acids; therefore, 5-HTP can be taken with meals without reducing its effectiveness.
5-HTP has been shown to have a beneficial impact on mood, sleep, carbohydrate cravings, and discomfort associated with fatigue. Numerous studies of individuals with negative mood status have shown significant positive response with 50-300 mg of 5-HTP daily.
To further facilitate serotonin production, Thorne’s 5-HTP formula contains pyridoxal 5′-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin. 5-HTP is commercially produced by extraction from the seeds of the African plant, Griffonia simplicifolia. Each lot is thoroughly tested for contaminants, including Peak X, and is Peak X free.
Warnings
Allergy Warning
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
Pregnancy Warning
If pregnant or nursing, do not use this product.
Interactions/Contraindications
5-Hydroxytryptophan should be used with caution in an individual currently being treated with an SSRI, MAO inhibitor, or other antidepressant medication.
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