Gut Brain Align™

Gut Brain Align™

The Science

Gut Brain Align by NeuroScience Inc delivers dispersible powdered ingredients to promote gut wall integrity, GI cellular health and replication, microbiome diversity, balanced immune responses, and emotional stress resilience.

Dysfunctions in gut brain interactions are found in 40% of people worldwide

• 60% first experienced stress-related mental health issues

Physical or perceived stress impact gut physiology via:

• GI motility and secretion
• Increases in intestinal permeability
• Increases in visceral perception (gut discomfort)
• Negative effects on microbiota composition, function
• Decreased regenerative capacity of GI mucosa, mucosal blood flow

Balancing role of GABA in the gut

GABA is an inhibitory neurotransmitter that balances excitatory neurotransmitter glutamate (synthesized from glutamine) CRH influences the colonic gut barrier by disrupting tight junction proteins and increasing permeability, cytokines, and mast cell degranulation

• GABA inhibits CRH | Glutamate promotes CRH

GI cellular health

Stress modulates peptides (i.e. tissue repairing CGRP) that negatively impact the health and regeneration of GI tract cells

• Uridine downregulates the enzyme (SA bgal) associated with stagnant cell replication, thereby reducing intestinal cellular age
• Aloe upregulates the PI3K-AKT pathway, a signaling pathway for biological processes like cell survival, proliferation, and angiogenesis
• DGL is shown to prolong the life span of surface cells in the stomach while research shows glutamine supporting intestinal cell proliferation

Gut serotonin and SERT

• In the intestinal epithelium, serotonin modulates secretion, motility, immune signaling, and nociception
• Enterochromaffin cells (EC) produce serotonin while SERT recycles it
• Immune mediators decrease SERT function, leading to excess serotonin in the colon and plasma
• Research found downregulation of TPH1 and increased SERT function reduces motility

Saffron is shown in patients with gut issues to

• Reduce diarrhea events, decrease gut immune markers, and aid bacteria that increase mucin expression (tight junction health)
• Balance serotonin secretion and SERT function
• Promote BDNF levels, dopamine release, mood stability, and feeling calm

Ingredients

Amino Acid:

• GABA
• L-glutamine

Botanical:

• Aloe vera
• Deglycyrrhizinated licorice root extract
• Marshmallow
• Okra
• Saffron

Vitamin/Mineral:

• Vitamin B6

Other:

• Uridine

Suggested Use