B-Complex with Metafolin and Intrinsic Factor
B-Complex with Metafolin and Intrinsic Factor by Douglas Laboratories, is a comprehensive B supplement providing essential B vitamins and intrinsic factor, a nutrient necessary for optimal vitamin B12 absorption.
B-Complex with Metafolin and Intrinsic Factor is unique among other B complex vitamins as it contains Metafolin®, a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF).
Studies indicate that methylcobalamin, a coenzyme form of B12, may be better utilized and better retained in the body. Intrinsic factor is a protein produced by cells in the stomach lining and is needed for the intestines to absorb vitamin B12 efficiently.
As co-enzymes, the B vitamins are essential components in most major metabolic reactions. They play an important role in energy production, including the metabolism of lipids, carbohydrates, and proteins. B vitamins are also important for blood cells, hormones, and nervous system function.
As water-soluble substances, B vitamins are not generally stored in the body in any appreciable amounts (with the exception of vitamin B-12). Therefore, the body needs an adequate supply of B vitamins on a daily basis.
Thiamin, riboflavin, and niacin are all essential coenzymes in energy production.
Thiamin is converted quickly into thiamin pyrophosphate, which is required for glycolytic and Krebs cycle reactions. Thiamin also appears to be related to nerve impulse transmission.
Riboflavin is a component of the coenzymes FAD and FMN, which are intermediates in many redox reactions, including energy production and cellular respiration reactions. Niacin is also a component of the coenzymes NAD and NADP, which are involved in energy production, as well as biosynthetic processes.
Vitamin B-6 is a coenzyme in amino acid metabolism. It is necessary for the metabolism of homocysteine and the conversion of tryptophan into niacin. Vitamin B-6 dependent enzymes are also needed for the biosynthesis of many neurotransmitters, including serotonin, epinephrine, and norepinephrine.
Methylcobalamin (vitamin B- 12) and folate are coenzymes in DNA and RNA metabolism. Both of these B vitamins assist in homocysteine metabolism. Folate serves as a methyl donor and methylcobalamin as a coenzyme in the conversion of homocysteine to methionine.
Studies indicate that methylcobalamin, a coenzyme form of B12, may be better utilized and better retained in the body.
Metafolin® is a patented, natural form of (6S) 5- methyltetrahydrofolate (5-MTHF). 5-MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health, as it participates as a cofactor in a reaction that involves the remethylation of homocysteine to methionine.
Unlike synthetic folic acid, 5-MTHF can be used directly by the body, without the need for an additional conversion via the enzyme (5,10-methylenetetrahydrofolate reductase (MTHFR)).
B-Complex with Metafolin and Intrinsic Factor may be useful for individuals who want to supplement with a complete array of B vitamins and related nutrients.
One vegetarian capsule contains:
Thiamine – 50 mg (Vitamin B-1, as thiamine HCL)
Riboflavin – 20 mgÂ (Vitamin B-2, Riboflavin-5-Phosphate)
Niacin – 50 mg (Vitamin B-3, as Niacinamide)
Vitamin B-6 – 20 mgÂ (as Pyridoxal-5 Phosphate)
Folate (as 5-MTHF, MetafolinÂ®) – 400 mcg
Vitamin B-12 (as methylcobalamin) – 500 mcg
Biotin – 300 mcg
Pantothenic Acid – 50 mgÂ (Vitamin B-5, as d-calcium pantothenate)
Intrinsic Factor (from porcine) – 20 mg
Adults take 1 B-Complex with Metafolin and Intrinsic Factor capsule, one to two times daily or as directed by one of our health coaches.
No adverse side effects have been reported.
Store in a cool, dry place, away from direct light. Keep out of reach of children.