Endocrine Complete by Douglas Laboratories is a comprehensive combination of vitamins, minerals, nutrients and phytotherapeutic compounds specifically formulated to provide support of endogenous hormone production by the endocrine system, including thyroid, adrenal, pituitary, gonadal and insulin function.
Endocrine Complete includes a wide variety of herbs that act as hormonogenic agents, a subclass of phytocrine activities that maintain endocrine gland health, first defined by Joseph J Collins, RN, ND in 2005.
As a Hormone Specific Multi-Nutrient, this formulation can be used as a foundation of hormone health with any of the Hormone Specific Formulations manufactured by Douglas Labs, and formulated by Dr. Collins.
Vitamins and minerals are used as cofactors for the various enzymes throughout the body that affect the health of every tissue. Proper levels of vitamins and minerals are required for both the production of hormones, and the ability of tissues to respond to hormones.
Studies show that a high percentage of adults in North America and other developed areas eat less than the minimum daily allowance of 10 or more essential nutrients.
In addition to inadequate dietary intake of endocrine essential nutrients, the function of nutrients may be limited because of genetic variations that limit the conversion of the nutrient to its activated form. These genetic limitations are recognized as single nucleotide polymorphisms (SNPs).
Specific SNPs are known to affect the conversion of beta-carotene to vitamin A. The conversion of folate to its active form L-methylfolate is also limited due to SNPs. Activated vitamin B-6, as well as the methylated form of vitamin B-12 is also required for optimal endocrine health.
In addition to the general benefits of vitamins, mineral and other nutrients, there are a number of very hormone specific benefits from each. For example, folate, best used as L-methylfolate, the most active form, is required for proper health of gonadal and adrenal tissue.
Vitamin B-12, as methylcobalamin, is required to maintain adequate levels of estrogen and progesterone and modulate cortisol levels. Riboflavin and thiamine are required for proper metabolism of thyroid hormones as well as the adrenal gland hormones.
Benfotiamine, a lipid soluble form of thiamine, supports insulin synthesis and healthy glucose metabolism. Vitamin K benefits go beyond bone health, as vitamin K helps to control the insulin response.
Endocrine Complete Phytocrine Blend
Pituitary Support: Three important axes of the anterior pituitary gland include the hypothalamic-pituitary- adrenal axis (HPA), the hypothalamic-pituitary-gonadal axis (HPG), and the hypothalamic-pituitary-thyroid axis.
The function of these axes may be affected by aging and stress, with senescence of these axes resulting loss of homeostasis in the adrenal, gonadal and thyroid systems. Bupleurum falcatum, Rehmannia glutinosa, Panax ginseng & Rhodiolia rosea supports HPA axis function.
Withania somnifera, Panax ginseng & Rhodiola rosea support HPG axis function. Withania somnifera supports HPT axis function.
Adrenal Support: Adrenocorticotropic hormone (ACTH) from the anterior pituitary gland preserves adrenal weight and function. Bupleurum falcatum, which contributes to the release of ACTH from the pituitary gland, results in healthy adrenal function and the ability of the adrenal glands to respond to stress.
Rehmannia glutinosa also has adrenotrophic properties and helps the body respond to stress. Panax ginseng supports adaptation abilities by maintaining baseline levels of ACTH, and also by modulating excessive stress induced ACTH production.
Rhodiolia rosea helps to decrease the stress-induced negative changes of ACTH and cortisol levels.
Gonadal Support: The gonadotrophic hormones from the anterior pituitary gland include Luteinizing hormone (LH) and Follicle-Stimulating Hormone (FSH). These hormones support function of testes and ovaries. LH promotes sex hormone production, and FSH promotes oogenesis and spermatogenesis.
Withania somniferasupports healthy serum levels of LH, and subsequently serum testosterone in human studies. Panax ginsengsupports both healthy FSH and LH levels in human studies.
Rhodiola rosea contains salidroside, which has a protective effect on the function of LH in the hypothalamic-pituitary-gonadal axis and can help maintain testosterone production.
Thyroid Support: Thyrotrophic cells in the anterior pituitary gland produce Thyroid-Stimulating Hormone (TSH), which preserves thyroid gland weight and function, and promotes the release of thyroid hormones. Thyroid hormones are produced by the thyroid gland under the influence of TSH.
Forskolin, an active ingredient in Coleus forskkohlii helps with T3 & T4 secretion from thyrocytes in a fashion similar to TSH, including organification of iodine though independent from TSH.
Withania somnifera supports hypothalamic- pituitary-thyroid axis function and also supports normal thyroid hormone production by direct action on the thyroid gland. Rhodiola rosea was shown to help normalize the stress-induced negative changes of thyroxine and triiodothyronine concentrations.
Insulin Support: Pancreatic beta-cells produce insulin based on the needs of the body. Gymnema sylvestre is beneficial for supporting healthy beta-cell function. Panax ginseng and Withania somnifera have the ability to maintain healthy blood glucose levels and support pancreatic beta-cells.
Rehmannia glutinosa can support the insulin response by helping promote glucose utilization and balancing cortisol levels.
Endocrine Complete may be a useful dietary supplement for those who wish to consume the essential nutrients plus herbs for hormone health and endocrine system support.
Serving Size 4 Vegetarian Capsules:
- Vitamin A – 5000 IU
(as 80% beta carotene/20% Vitamin A Palmitate)
- Vitamin C (as Ascorbic Acid) – 500 mg
- Vitamin D-3 (as Cholecalciferol) – 1,000 IU
- Vitamin E – 100 IU
(as d-alpha tocopheryl succinate plus mixed tocopherols)
- Vitamin K-2 (as Menaquinone-7) – 40 mcg
- Thiamine (as Thiamine HCl) – 25 mg
- Riboflavin (as Riboflavin-5-phosphate) – 10 mg
- Niacin/Niacinamide – 30 mg
- Vitamin B-6 (as Pyridoxal-5-phosphate) – 20 mg
- Folate (as L-Methylfolate, Metafolin) – 400 mcg
- Vitamin B-12 (as Methylcobalamin) – 250 mcg
- Biotin – 300 mcg
- Pantothenic Acid – 25 mg
(as Calcium Pantothenate)
- Calcium (as Calcium Citrate Malate) – 50 mg
- Iodine (from Kelp) – 150 mcg
- Magnesium (as Magnesium Citrate) – 50 mg
- Zinc (as Zinc Monomethionine, Opti-Zinc) – 15 mg
- Selenium (as l-Selenomethionine) – 100 mcg
- Copper – 0.25 mg
(as Copper Amino Acid Chelate)
- Manganese – 2 mg
(as Manganese Amino Acid Chelate)
- Chromium – 120 mcg
(as Chromium Amino Acid Chelate)
- Molybdenum – 100 mcg
(as Molybdenum Amino Acid Chelate)
- Inositol – 25 mg
- Boron (as Boron Citrate) – 2 mg
- Benfotiamine – 25 mg
Endocrine Complete A Phytocrine Proprietary Blend – 500 mg
- Bupleurum falcatum root Extract
- Rehmannia glutinosa root Extract
- Rhodiola rosea root Extract (standardized to 3% rosavins)
- Ashwagandha root and leaf Extract (Withania somnifera, standardized to a minimum of 10% withanolide glycoside conjugates and 32% oligosaccharides)
- Coleus forskohlii Extract (root, standardized to 10% forskolin)
- Gymnema sylvestre Extract (leaf, standardized to 25% gymnemic acids)
- Panax ginseng Extract (root, standardized to 3% ginsenosides)
Other ingredients: Hydroxypropyl methylcellulose (capsule), cellulose and silica
Adults take 4 capsules daily with food, or as directed by one of our health coach professionals. This product is best taken in the AM or Noon.
This product contains Vitamin K, which interferes with the prescription drug Coumadin
(Warfarin). Consult your physician before taking this product.
If pregnant, nursing, or taking prescription medications, consult your healthcare practitioner before taking this product.
No adverse side effects have been reported.
Store in a cool, dry place, away from direct light. Keep out of reach of children.